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Though associated with early multiple sclerosis, this symptom is not in itself diagnostic. L'hermitte's sign may also be caused by radiation injury or as a side effect of radiotherapy in the region of the neck. Trauma to the cervical portion of the spinal cord, cervical cord tumour, cervical spondylosis, or even a simple vitamin B12 deficiency may also cause the nerve damage which results in this symptom. It is also be experienced in patients with a particular type of brain tumour - a meningioma - in the base of the skull. © Multiple Sclerosis Resource Centre (MSRC)
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