Multiple Sclerosis Resource Centre
  • Home
  • MSRC Grand Opening 30/05/12
  • About MS
  • MSRC Services
  • Get Involved
  • MS Research News
  • MSRC Groups
  • Useful Resources
  • Welcome To Josephs Court, MS Centre Of Excellence
  • Advertising
  • Best Bet Diet Group
  • E-Newsletter
  • Contact Us
  • Investor in People
    You are here : Home » MS Research News » New Discoveries » Tetanus Vaccine and Possible MS Protection

    Tetanus Vaccine and Possible MS Protection

    A A A
    [Print this page]

    Share |

    Tetanus jab may curb multiple sclerosis risk
    Vaccination against tetanus may offer protection against the development of multiple sclerosis (MS), according to a new study from Boston-based researchers.

    Dr. Miguel A. Hernan and colleagues from Harvard School of Public Health pooled data from nine studies published between 1966 and 2005 that looked at the association between tetanus vaccination and MS risk. Analyses centered on a total of 963 MS cases and 3126 controls.

    They found that a history of having been immunised against tetanus was associated with a 33 percent decrease in risk of MS.

    The results of the current meta-analysis suggest that tetanus vaccination may prevent or delay the development of MS. The investigators call for further epidemiologic research to assess the role of timing of immunisation and the number of doses associated with this protective effect.

    The hypothesis that tetanus immunity may protect against MS is supported by the findings of two recent prospective studies, Hernan and colleagues note in a report in the journal Neurology.

    The biologic mechanism by which the tetanus vaccination may protect against MS is unclear, according to the authors. They note, however, that vaccination with tetanus toxoid may shift the T helper cell immune response from a proinflammatory Th1 response to an anti-inflammatory Th2 response.

    Immunising with the tetanus toxoid "could be a promising approach for the treatment and prevention of MS and other Th1 cell mediated autoimmune disorders," the clinicians charge.

    SOURCE: Neurology July 25, 2006. (01/08/06)

    © Multiple Sclerosis Resource Centre

    Related Items
    Abnormal Liver Tests and MS
    Aluminium and Multiple Sclerosis
    Antagonist compounds
    Antibodies, B Cells,T-Cell Activation, Immune Response
    Apolipoprotein D
    Bacteria & MS
    Biomarkers and MicroRNA
    Blood tests
    Bone Marrow Cells and MS Treatment
    Bowmann-Birk Inhibitor Concentrate (BBIC)
    Brain Atrophy, Lesion Loads, White and Grey Matter
    Brain Inflammation
    Brain Iron Deposits
    Calcium Binding Proteins
    Cerebro-Spinal Fluid & Spinal Cord
    Chronic Cerebrospinal Venous Insufficiency (CCSVI)
    CXCL1, 7, 12
    Cytokines & Chemokines
    Dendritic Cells
    Estrogen Receptors
    Fibrinogen, Mac-1 and Microglia
    Histamine and MS
    Hormones And MS Research
    Infections and Multiple Sclerosis Relapses
    JAK-STAT inhibitors
    Kallikrein 6
    Lipids & MS
    Medical Imaging
    Mycoplasmas And Bacteria
    N-acetylglucosamine (GlcNAc) & Glucosamine
    Natural Interferon Beta
    Natural Killer Cells
    Nerve and Brain Cell Research
    Olig 1 Gene Discovery
    Oligodendrocytes and Astrocytes
    Pesticides and Multiple Sclerosis
    Plasma Exchange
    Potential Viral Causes of MS
    Recombinant Human Erythropoietin
    Regeneration Research
    RNA and RNAi
    Synthetic Small Molecules
    The Blood Brain Barrier
    Tremors And MS
    Uric Acid
    Urinary Problems
    Vascular Function And MS
    Vision and MS

    Did you find this information useful? Would you like to comment on this page? Let us know what you think! We welcome all comments and feedback on any aspect of our website - please click here to contact us.