Multiple Sclerosis Resource Centre
  • Home
  • MSRC Grand Opening 30/05/12
  • About MS
  • MSRC Services
  • Get Involved
  • MS Research News
  • MSRC Groups
  • Useful Resources
  • Welcome To Josephs Court, MS Centre Of Excellence
  • Advertising
  • Best Bet Diet Group
  • E-Newsletter
  • Contact Us
  • Investor in People
    You are here : Home » MS Research News » New Discoveries » Abnormal Liver Tests and MS

    Abnormal Liver Tests and MS

    A A A
    [Print this page]

    Share |


    Multiple Sclerosis Linked to Abnormal Liver Test Results
    Multiple sclerosis has been linked to abnormal liver test results according to research findings announced by the Multiple Sclerosis Society of Canada. The study was published in the October 10 edition of Neurology.

    According to Dr. Helen Tremlett, assistant professor at the University of British Columbia and lead researcher on the study, the results could mean that people with MS need to take extra care when using medications that might affect their liver and be alert to any possible symptoms of liver disease.

    "I would recommend people with MS have their liver tested as a routine part of their care when being treated with drugs known to affect the liver," Dr. Tremlett says. "In addition, people need to inform their doctor immediately if there is any presentation of liver disease symptoms such as jaundice (yellow skin or yellowing of the whites of the eye), itchy skin and unexpected fatigue."

    The liver is the organ responsible for plasma synthesis, drug detoxification and digestion. Diseases of the liver include hepatitis and cirrhosis.

    To make the link, the researchers used data from the Sylvia Lawry Centre for MS Research in Germany, the largest database of MS clinical trial information in the world. In all, medical information from 813 people with MS enrolled in various clinical trials from North America, Australia and Europe was analysed. The study was funded by the MS Society of Canada.

    Over a two-year period, there was an over three-fold increased risk of a person with MS having an elevated liver test result compared to expectations. An elevated test result indicates that liver enzymes have leaked out of their cells. This leakage into the blood stream may be an indicator of liver cell damage.

    Over-the-counter medicines like acetaminophen or herbal remedies may cause elevated levels of liver enzymes in the blood.

    "People with MS or any chronic disease need to carefully monitor their medications," notes Dr. William J. McIlroy, national medical advisor for the MS Society of Canada. "Both the patient's doctor and their pharmacist should be fully aware all the therapies being taken to ensure symptoms and test results are not misinterpreted."

    An earlier study also funded by the MS Society of Canada and led by Dr. Tremlett showed that certain prescribed MS drugs - commonly described as "beta interferons" - can increase the risk of liver disturbances. However, the current study examined those who were not on beta interferon treatment.

    "Although beta interferons do further increase the risk of an elevated test, we know now that abnormal liver tests can result independent of this treatment," says Dr. Tremlett. "The next step is to determine why this is and hopefully add another piece to the complex puzzle that is MS."

    Multiple sclerosis is an unpredictable, often disabling disease of the central nervous system - the brain and spinal cord. The disease attacks the protective myelin covering of the central nervous system, causing inflammation and often destroying the myelin in patches. The severity of MS and its progression varies from person-to-person. Symptoms of MS include blurred vision, extreme fatigue, loss of balance, problems with coordination and painful stiffness of muscles among many others.

    It is estimated that 55,000 - 75,000 Canadians have MS. A recent survey by Leger Marketing showed that half of Canadians know someone with MS. The MS Society of Canada is the highest per capita funder of MS research in the world. In 2006, the MS Society allocated $4.5 million in new research funding.

    Source: CNN Matthews (01/11/06)

    © Multiple Sclerosis Resource Centre

    Related Items
    AlphaB-crystallin
    Aluminium and Multiple Sclerosis
    Antagonist compounds
    Antibodies, B Cells,T-Cell Activation, Immune Response
    Apolipoprotein D
    Bacteria & MS
    Biomarkers and MicroRNA
    Blood tests
    Bone Marrow Cells and MS Treatment
    Bowmann-Birk Inhibitor Concentrate (BBIC)
    Brain Atrophy, Lesion Loads, White and Grey Matter
    Brain Inflammation
    Brain Iron Deposits
    Calcium Binding Proteins
    Cerebro-Spinal Fluid & Spinal Cord
    Chronic Cerebrospinal Venous Insufficiency (CCSVI)
    CRMP-2
    CXCL1, 7, 12
    Cytokines & Chemokines
    Dendritic Cells
    Estrogen Receptors
    Fibrinogen, Mac-1 and Microglia
    HDL
    HERV-Fc1
    Histamine and MS
    Hormones And MS Research
    Immunoglobulins
    Infections and Multiple Sclerosis Relapses
    Interleukin-1beta
    JAK-STAT inhibitors
    Kallikrein 6
    Lipids & MS
    Medical Imaging
    Mycoplasmas And Bacteria
    N-acetylglucosamine (GlcNAc) & Glucosamine
    Natural Interferon Beta
    Natural Killer Cells
    Nerve and Brain Cell Research
    Neurosteroids
    Olig 1 Gene Discovery
    Oligodendrocytes and Astrocytes
    Pesticides and Multiple Sclerosis
    PKC-theta
    Plasma Exchange
    Potential Viral Causes of MS
    Proteomics
    Recombinant Human Erythropoietin
    Regeneration Research
    RNA and RNAi
    Synthetic Small Molecules
    Technology
    Tetanus Vaccine and Possible MS Protection
    Tetramers
    The Blood Brain Barrier
    Tremors And MS
    Uric Acid
    Urinary Problems
    Vascular Function And MS
    Vision and MS


    Did you find this information useful? Would you like to comment on this page? Let us know what you think! We welcome all comments and feedback on any aspect of our website - please click here to contact us.