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    You are here : Home » MS Research News » Drugs » RPI-78M

    RPI-78M

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    Nutra Pharma receives patent for their Multiple Sclerosis drug
    NutraPharama LogoNutra Pharma Corporation, a biotechnology company that is developing treatments for Multiple Sclerosis (MS), Human Immunodeficiency Virus (HIV/AIDS), Adrenomyeloneuropathy (AMN) and Pain, announced today that its wholly-owned subsidiary, ReceptoPharm, has received approval from the United States Patent and Trademark Office (USPTO) for its patent describing the composition of matter and the use of neurotoxins for the treatment of Multiple Sclerosis (MS).

    "This is the third patent to be issued to our ReceptoPharm subsidiary in the last 16 months," commented Rik J Deitsch, Chairman and CEO of Nutra Pharma Corporation. "These patents are key to the continuing development of our pipeline and provide the value for eventual commercialization of the technology or out-licensing of the drugs. We currently own or license twelve patents that protect a broad range of drug and medical device technologies," he explained.

    The patent (US 8,034,777), titled "Modified anticholinergic neurotoxins as modulators of the autoimmune reaction," describes a composition of matter and method of its use for the treatment of multiple sclerosis in humans. The composition is a modified anticholinergic alpha-neurotoxin.

    "This patent represents a key addition to our intellectual property portfolio," commented Dr. Paul Reid, CEO of ReceptoPharm. "While the Company has been focused on our pain therapies, we continue to support our deep, clinical pipeline. We will be supporting further pre-clinical and clinical studies in an effort to move our MS therapy forward and to eventual approval," he concluded.

    Multiple Sclerosis (MS) is thought to be an autoimmune disease that primarily causes central nervous system problems. In MS, the insulating fatty material surrounding the nerve fibers, also known as myelin, which functions to speed signaling from one end of the nerve cell to the other, is attacked by cells of the immune system causing problems in signal transduction.

    According to the Accelerated Cure Project for Multiple Sclerosis, a national nonprofit organization, 400,000 people in the US are affected by MS and another 2 million globally. Nutra Pharma's MS drug, RPI-78M, has shown efficacy in animal models (EAE) for MS and the Company is planning new animal studies to gain more insight into the levels of protection that the drugs afford. In one study conducted in August 2007, all members of an untreated animal control group developed signs of disease with different levels of paralysis/muscle weakness. A similar group in the August 2007 study treated with RPI-78M showed no disease in 90% of the animals in both acute and chronic applications of the test. Moreover, there were no toxicities reported though the animals received doses the equivalent of 280 times a human dose.

    Source: Market Watch Copyright © 2011 MarketWatch, Inc (19/10/11)

    Nutra Pharma Announces ReceptoPharm Patent for a Method of Treating Multiple Sclerosis
    Nutra Pharma Corp. a biotechnology company that is developing drugs for HIV and Multiple Sclerosis has today announced that its drug discovery division, ReceptoPharm, has filed a patent for a method of treating autoimmune diseases, including Multiple Sclerosis (MS) and Rheumatoid Arthritis.

    The patent discusses a method of treatment that uses ReceptoPharm's lead drug candidate, RPI-78M, to induce gamma-interferon and interleukin-27 (IL-27). IL-27 is a recently discovered and important anti-inflammatory regulator in cells of the immune system.

    "We are pleased to announce this important discovery by ReceptoPharm," commented Rik J Deitsch, Chairman and CEO of Nutra Pharma Corporation. "Recently, larger biotechnology companies, including Genentech, have shown interest in ways to control this pathway as a means to treat several autoimmune diseases. Some have even proposed the direct use of IL-27 to down regulate the autoimmune process," he added.

    The ReceptoPharm patent provides a new way of controlling autoimmune diseases. Inducing IL-27 and gamma-interferon shut down the inflammation process by influencing the release of another interleukin, IL-17, that is a newly discovered component in maintaining the inflammation and autoimmune process.

    "This discovery is significant to our continued research and development, as it identifies the mechanism of action for RPI-78M," explained Paul Reid, CEO of ReceptoPharm, Inc. "We believe that our drug is the first to induce the expression of IL-27, which represents a novel way to approach the treatment of several autoimmune diseases," he concluded.

    In March, ReceptoPharm received notification of acceptance of its paper, entitled "Alpha-Cobratoxin as a possible therapy for Multiple Sclerosis; a review of the literature leading to its development for this application," for publication in the Critical Reviews in Immunology special conference issue. In addition, the Company recently announced its nonbinding letter of intent with Nanogene Biotechnology to create a joint venture in China aimed at developing its antiviral drug, RPI-MN, for the Chinese market.

    Source: Nutra Pharma Corp.(11/04/07)

    Nutra Pharma Reports Preclinical Results of RPI-78M in Multiple Sclerosis to Be Presented at Scientific Meeting
    Nutra Pharma Corp. a biotechnology company that owns rights to intellectual property related to the development of drugs for HIV and Multiple Sclerosis, has announced that the studies using RPI-78M in an animal model of Multiple Sclerosis (MS) have been accepted for presentation and publication. RPI-78M is the lead drug candidate of Nutra Pharma's holding, ReceptoPharm, Inc. and is being studied in preclinical assays for its efficacy in treating MS.

    EAE (experimental allergic encephalomyelitis) is the standard benchmark animal methodology for the study of MS. ReceptoPharm's drug, RPI-78M, proved to be very effective in preventing the onset of disability in acute and chronic models of the disease. The drug was also very effective in preventing the infiltration of immune cells into the central nervous system. This research was conducted to confirm the reported benefits of similar products in immune mediated diseases such as Multiple Sclerosis and Rheumatoid Arthritis.

    These results will be presented by Dr. Adel Mohamed at the Rocky Mountain Biotechnology Symposium (RMBS). The Conference is being held at the Rose-Hulman Institute of Technology in Terre Haute, Indiana on April 7-9. The RMBS has been held annually since 1964. This presentation will also be published in nationally distributed Conference Proceedings through the Instrument Society of America (ISA).

    "We are very pleased to start presenting our findings within the scientific community," commented Rik Deitsch, CEO of Nutra Pharma. "The positive results of the animal model as well as the strong findings from the microarray analysis support our move into Phase II human clinical trials," he added.

    The study was conducted by researchers in the Department of Anatomy and Cell Biology at the University of Saskatchewan. The lead researcher, Associate Professor Dr. Adel Mohamed, reported that the preliminary results indicate that RPI-78M inhibited the development of acute as well as the relapsing phases of the EAE in Lewis rats. The report also stated that, if confirmed, these preliminary results suggest that it is of interest to initiate clinical trials on MS patients using the drug. The conclusion of the report stated that it seems within the realm of possibility that RPI-78M may be as, if not more, therapeutically efficacious as the current interferon drugs in the treatment of neurologic disease.

    "The EAE study yielded the results we expected and we are excited at the reduced CNS infiltration by lymphocytes," commented Paul Reid, PhD, CEO of ReceptoPharm. "It is also worth mentioning that the drug has proven to have multi-faceted properties relative to current therapies in MS. It demonstrates the same properties as the current MS therapies combined, in addition to having analgesic properties and minimal toxicity," he added.

    There has been a great deal of interest surrounding research in Multiple Sclerosis therapies. There are currently four drugs on the market for the treatment of the disease. A fifth drug, Tysabri, was voluntarily pulled from the marketplace in February 2005 by the drug's manufacturers, Biogen-Idec and Elan.

    Source: Nutra Pharma Corp. (02/10/06)

    © Multiple Sclerosis Resource Centre

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