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    You are here : Home » Get Involved » MSRC Interactive » Tysabri® User Diaries

    Tysabri® User Diaries

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    TysabriTo aid those who may have been prescribed Tysabri® or those thinking of asking their Neurologist to prescribe Tysabri®.

    We at the MSRC have enlisted the help of a number of people with MS who are now currently taking Tysabri® to provide some insight into how they went about getting given the drug and how the monthly infusions have changed, or not, their condition.

    If you are currently taking Tysabri®, and would like to join our panel of "Diarists" please contact the MSRC Webmaster at [email protected]

    Tysabri® Diarists

    Useful Tysabri® Information

    For more information on Tysabri please have a look at the "The Strength to Reach Your High HOPES" - Tysabri Information Booklet, UK patients please note this is a US publication, but contains much useful information.

    What is Tysabri®?

    TYSABRI® (Natalizumab) is a treatment approved for relapsing forms of Multiple Sclerosis in the United States and relapsing-remitting MS in the European Union.

    It is a recombinant humanised monoclonal antibody produced in murine myeloma cells. The specific mechanism(s) by which TYSABRI® exerts its effects in multiple sclerosis have not been fully defined. However, Pharmacodynamic data has shown that TYSABRI® administration increases the number of circulating leukocytes (including lymphocytes, monocytes, basophils, and eosinophils) due to inhibition of transmigration out of the vascular space. TYSABRI® does not affect the number of circulating neutrophils.

    According to data that have been published in the New England Journal of Medicine, after two years, Tysabri® treatment led to a 68% relative reduction (p<0.001) in the annualised relapse rate compared to placebo and reduced the relative risk of disability progression by 42-54% (p<0.001).

    In addition to the United States and European Union, Tysabri® is also approved for MS in Switzerland, Canada, Australia, New Zealand and Israel. Tysabri® was discovered by Elan and is co-developed with Biogen Idec.

    Source: Biogen Idec.

    © Multiple Sclerosis Resource Centre (MSRC)

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