Cleveland Clinic Center for Medical Art & Photography In CCSVI, vascular changes, like stenosis (narrowing) or reflux in valves can lead to reduced blood drainage from the brain.During 2009 a new theory on the possible cause of multiple sclerosis was reported by Dr Paolo Zamboni, Director Vascular Diseases Center, University of Ferrara, Italy. Chronic cerebrospinal venous insufficiency is described as a chronic problem (ongoing) where blood from the brain and spine has trouble getting back to the heart. It is caused by a narrowing in the veins (stenosis) that drain the brain and the spine. Blood takes longer to return to the heart, and it can reflux back into the brain and spine or cause oedema and leakage of red blood cells and fluids into the tissues of the brain and spine. Blood that remains in the brain too long creates a delay in deoxyginated blood leaving the head ("slowed perfusion"). This can cause hypoxia, a lack of oxygen in the brain. Plasma and iron from blood deposited in the brain tissue can also be very damaging leading to iron along with other unwelcome cells crossing the crucial brain-blood barrier. Further clinical trials are in process to verify Dr. Zamboni's CCSVI theory in relation to MS and the proposed "Liberation Procedure" treatment. CCSVI Page Links
MSRC Statement on CCSVI and Dr Paolo Zamboni’s work. © Multiple Sclerosis Resource Centre
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