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    You are here : Home » About MS » Multiple Sclerosis Treatments » MS Health Tips » Fluids

    Fluids

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    Keep Drinking Water
    WaterMany of us may already be aware of the importance of drinking enough water. Many people who experience continence problems stop drinking but please don’t. You will only end up dehydrated and may get a urine infection, which can trigger an MS relapse. Signs of a urine infection are cloudy & smelly urine & it may be painful to pass water. Signs of dehydration to watch for are dry skin, dark yellow urine, dry mouth, flushed skin & fatigue.

    Health experts now recommend drinking at least two litres, that’s 8 glasses of water a day and it really is water that is best for you too. Maybe you think you drink plenty of fluids with cups of tea, coffee and soft drinks. But tea, coffee and alcohol are diuretics & actually take water away from the body. This we don’t need especially if we have continence problems. They also flush out essential vitamins and minerals from the body.

    So what are the alternatives to tea and coffee? Let’s face it we don’t want to do without a good cuppa! Sometimes it isn't the actual tea, but it is the habit that matters. So try drinking herbal tea and especially Green tea, which is better for you being low in caffeine and containing anti-oxidants. Or maybe try another tea called Roobibush (Redbush) Tea, which also contains healthful antioxidants and is actually caffeine-free. There are lots of alternatives!

    Avoid Caffeine

    CoffeeResearch suggests that caffeine may be bad for Multiple Sclerosis. Researchers found that caffeine can block the adenosine receptor and thus lower the effectiveness of adenosine for suppressing inflammation.

    The adenosine molecule is a key player in regulating the immune system by halting inflammatory reactions. Dr Sitkovovsky, the trial leader, said it would be wise for people with MS to drink less coffee.

    Source:  Nature, 20th December 2001

    Drinking Green Tea
    Green TeaGreen Tea suppresses both TNFa and NO Nitric Oxide, which is very good for people with MS.

    Prevention of lifestyle-related diseases

    In the normal human life span, there occur lifestyle-related diseases that may be preventable with nontoxic agents. This paper deals with the preventive activity of green tea in some lifestyle-related diseases.

    Green tea is one of the most practical cancer preventives, as we have shown in various in vitro and in vivo experiments, along with epidemiological studies. Among various biological effects of green tea, we have focused on its inhibitory effect on TNF-alpha gene expression mediated through inhibition of NF-kappaB and AP-1 activation.

    Based on our recent results with TNF-alpha-deficient mice, TNF-alpha is an endogenous tumor promoter. TNF-alpha is also known to be a central mediator in chronic inflammatory diseases such as rheumatoid arthritis and multiple sclerosis.

    We therefore hypothesized that green tea might be a preventive agent for chronic inflammatory diseases. To test this hypothesis, TNF-alpha transgenic mice, which overexpress TNF-alpha only in the lungs, were examined. Expressions of TNF-alpha and IL-6 were inhibited in the lungs of these mice after treatment with green tea in drinking water for 4 months.

    In addition, judging from the results of a prospective cohort study in Saitama Prefecture, Japan, green tea helps to prevent cardiovascular disease. In this study, a decreased relative risk of death from cardiovascular disease was found for people consuming over 10 cups of green tea a day, and green tea also had life-prolonging effects on cumulative survival.

    These data suggest that green tea has preventive effects on both chronic inflammatory diseases and lifestyle-related diseases (including cardiovascular disease and cancer), resulting in prolongation of life span.

    Inhibition of inducible nitric oxide synthase gene expression and enzyme activity by epigallocatechin gallate, a natural product from green tea.

    Chronic inflammation has been implicated as the underlying factor in the pathogenesis of many disorders. In the past decade, inflammation-related endogenous production of reactive nitrogen species, similar to oxygen free radicals, has also been suggested as a risk factor for cancer, in addition to the well-studied exogenous nitroso compounds.

    Epidemiological, in vitro, and animal model studies have implicated green tea to be protective against nitroso compound-induced and inflammation-related cancer. Therefore, we investigated the effect of epigallocatechin-3-gallate (EGCG), one of the known biologically active catechins contained in green tea, on the production of nitric oxide (NO).

    We have shown previously that EGCG reduces NO. production as measured by nitrite accumulation in the culture medium.

    Expanding on this finding, in this report we show that EGCG may do so by two mechanisms: reduction of inducible nitric oxide synthase (iNOS) gene expression and inhibition of enzyme activity.

    Increased intrathecal nitric oxide formation in multiple sclerosis; cerebrospinal fluid nitrite as activity marker.

    Nitric oxide is formed from L-arginine by a family of enzymes: nitric oxide synthase (NOS). The inducible nitric oxide synthase is activated by cytokines and it has been suggested that activation of the enzyme gives rise to neurotoxic levels of reactive nitrogen oxides.

    This enzyme has been shown to be localised in multiple sclerosis (MS) lesions but the role of nitric oxide formation in the pathogenesis of MS is still unclear.

    Using capillary electrophoresis, we have analysed nitrite and nitrate in cerebrospinal fluid (CSF) and demonstrate increased levels of reactive nitrogen products in 17 patients with MS. The total levels of oxidised nitrogen products were significantly elevated in MS patients when compared with controls. In patients with active MS, nitrite levels were significantly increased when compared with controls and patients in remission.

    This is supportive of NOS induction in MS. We suggest that capillary electrophoresis analysis of nitrite and nitrate in CSF could provide a clinically useful way to determine disease activity in MS.

    © Multiple Sclerosis Resource Centre (MSRC) 

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